The folks at The Evidence Workshop are dreaming of a white Christmas. We don’t like to shovel, and we don’t like to shiver. But after Santa’s big ride, we’re heading up to Michigan’s Upper Peninsula (UP) for some downhill skiing. We’re not a skillful bunch, but skiing is an excuse to play in the snow and enjoy all 4 seasons the Midwest offers. Afterall, isn’t it the Swedes who say, “There’s no such thing as bad weather, only bad clothing?” They are probably right when it comes to staying warm and dry, but good clothing won’t prevent a ski-related injury.
So, before we closed the Shop for our usual January break, we did some research on Alpine ski injuries and learned that knee injuries are among the most common. We also bumped into a new clinical exam, called the lever sign test, for anterior cruciate ligament (ACL) injury. With any luck, we won’t need the test, and we hope you don’t, either. But here’s what we learned:
What is the lever sign test?
It’s a clinical test of ACL stability that is performed with the patient supine and the examiner’s closed fist under the proximal third of the calf. With the knee flexed slightly, the examiner’s other hand applies a downward force just proximal to the knee. If the ACL is intact, the heel will rise off the table, indicating a negative test. If the ACL has been disrupted, the patient’s heel will remain on the table, indicating a positive test.
Does the lever sign test have good face validity?
From the standpoint of mechanism-based reasoning, the test is sound. The developers argue that, when a fist is placed beneath the calf, the knee flexes approximately 30°. In this position, the origin and insertion of the ACL are maximally separated. The ligament is taut. Because the ACL’s job in life is to prevent posterior displacement of the femur with respect to the tibia, a downward force on the thigh will further increase tension on the ACL, causing the knee to extend and the foot to rise off the table. If the ACL is torn, there is nothing to counteract the posterior movement of the thigh. The foot stays put.
Did we need a new ACL test?
Maybe.
Developers argue that the lever sign test is easier than the tests we grew up with (i.e., anterior drawer, Lachman, pivot shift). The older tests require that we stabilize the thigh while manipulating the leg. During the lever sign test, the table supports the whole lower limb.
Does the lever sign test work?
Yes, but its more trustworthy when you get a positive test result, as compared to a negative result.
A good diagnostic test will distinguish (with a high level of certainty) between people with and without a condition. A test’s ability to do so is measured in several ways, including sensitivity, specificity, and likelihood ratio. A recent systematic review with meta-analysis by Abruscado et al. provides the following pooled values for the lever sign test:
Sensitivity 0.77
Specificity 0.90
LR+ 6.60
LR- 0.22
Large values for sensitivity and specificity are good. The closer to 1, the better. So, the lever sign test is quite specific, but not as sensitive. Let’s see what that means.
A perfectly specific test is one that detects all true negatives. It’s most valuable when it’s positive. I know that’s counterintuitive, but let’s think about it this way. A specific test is so darn good at detecting true negatives, it will never miss one. So, when the specific test is positive, you can be sure the patient has the condition. You may have seen this concept summarized in the mnemonic device, SpPin, which reminds us that when a Specific test is Positive, you can rule-in the condition.
A perfectly sensitive test is one that detects all true positives. It’s most valuable when it’s negative. Here we go again. A sensitive test is so good at detecting true positives, it will never miss one. So, when it’s negative, you can be sure your patient is free from the condition. Here, we use SnNout to remind us that when a Sensitive test is Negative, you can rule-out the condition.
In summary, the lever sign test is really trustworthy when it provides a positive test, but less so when it gives a negative test.
The same conclusions are evident in LR+ and LR-. These abbreviations stand for positive(+) and negative(-) likelihood ratio (LR). If you are an old-timer, you probably did not learn LR+ and LR- in school. But these concepts are standard fare in evidence-based practice courses these days. While you track down a colleague under 40 to explain it, let this explanation suffice.
A good diagnostic test should have a high LR+ anda low LR-. Think, plus(+) high, minus(-) low.
LR+ represents the likelihood of a getting a positive test in someone with the condition as compared to someone without it. In theory, we want LR+ to be infinitely large, meaning the test is positive only in those who have the condition.
LR- is the likelihood of a positive test in someone without the condition as compared to someone with it. In theory, we want LR- to be zero, meaning that the test is never positive in people without the condition.
Some sources suggest that a good diagnostic test should have LR+ >10 and/or LR- <0.10. But, in our experience, many clinical tests in PT don’t score that well. So, 6.60 an 0.22 are not too shabby.
How can this information help diagnose ACL injury?
Consider this scenario:
A patient walks into your clinic with loaner crutches from the nearby ski lodge. She reports knee pain and some swelling. She tells you she was skiing with her family, caught her tip in some deep powder, twisted, and felt a pop. You suspect an ACL tear. Given the incidence of ACL tears near the ski hill and your knowledge of the incident, you estimate that she has a 75% chance of a torn ACL. You do the lever sign test and get a positive result. You pull out your handy nomogram tool for diagnostic testing and put a dot on the left-hand side at 0.75. Then you put a dot in the middle at 6.60. Finally, you connect the dots and extend the line to the right-hand side. You read a value of 0.95, which means that there is a 95% chance that her ACL is torn. You deliver the bad news.
Had your patient tested negative on the lever sign test, you would have placed the middle dot on 0.22, connected the dots, and learned that the post-test chance of ACL tear is 40%. That’s a disappointing answer. Not because her ACL might be OK, but because you’re not sure; 40% is a somewhat equivocal conclusion. A negative result on a test with a very small LR- will push you toward 0% chance of injury, just like the LR+ above pushed you to near certainty of injury. Again, the lever sign test is a little better at ruling-in ACL injury than it is at ruling it out.
Thanks for reading. Very best wishes for a relaxing holiday break, and Merry Christmas to those who are celebrating. We’ll see you in February when Shop Talk returns. As always, you can find additional resources at the end of this post. If you like what we’re doing, consider supporting our work by buying us a coffee at https://www.buymeacoffee.com/ptworkshop.
Dr. Sheila Schindler-Ivens started The Evidence Workshop to help clinicians integrate research evidence into patient care. She loves reading and interpreting research, and she believes that everyone can be a good consumer of the literature. She stresses a nuanced approach because all evidence is limited; yet a great deal of it is helpful. Optimal patient care demands a balanced understanding of the strengths and limitations of all types of evidence.
Sheila is an associate professor at Marquette University. She teaches evidence-based practice and directs a research program in stroke recovery. She is the recipient of the Edward Carroll Teaching Excellence Award and has published numerous peer reviewed articles. Her scholarship has been funded by several agencies, including the National Institutes of Health, American Heart Association, and Foundation for Physical Therapy Research. She lives in Shorewood, WI with her husband and two sons and enjoys running, swimming, and sleeping in.
Want to learn more?
https://www.buymeacoffee.com/ptworkshop/hydroxychloroquine-covid-19
https://en.wikipedia.org/wiki/Upper_Peninsula_of_Michigan
We specialize in transforming the lives of seniors, adults and teenagers with a wide array of diagnoses and conditions in their home or location of choice. You deserve to be your best self through good health and wellness. We would love to have the privilege to work with you or a loved one.
Request a FREE Consultation Today!